Effect of β-Cyclodextrin and Curcumin Inclusion Compound on Reducing Human Blood Lipid

Turmeric belongs to Zingiberaceae, gas-fragrant, bitter, pungent, widely distributed in southern China. According to the Compendium of Materia Medica, turmeric"Treating wind and arthralgia", modern medical treatment shows that turmeric has a variety of biological activities and pharmacological effects such as liver protection, anti-inflammatory, anti-oxidation, blood lipid reduction, and anti-cancer. Curcumin and its derivatives (known as curcuminoids) are bioactive components of the plant Curcuma longa. Throughout the ages, curcumin has been widely used in traditional Indian medicine and Chinese medicine to treat various diseases. However, curcumin has a major disadvantage, its low water solubility, instability under physiological conditions, low intestinal absorption, rapid metabolism in the body, resulting in its low bioavailability, it is difficult to be absorbed by the human body. According to the principle of similar compatibility, curcumin is easily soluble in non-polar organic solvents and difficult to dissolve in polar solvents, so it is difficult to be absorbed by the human body. Enlarging the molecular surface area of curcumin is closely related to improving bioavailability, and pure curcumin extract will accumulate in the human body. Only trace amounts of curcumin molecules are absorbed on the surface of the aggregates, and most of the curcumin is excreted.

ResearchersUseΒCyclodextrin substances, which are hydrophobic in the cavity, hydrophilic outside the cavity of the amphiphilic molecules, with a ring three-dimensional structure, the formationThe "cone-shaped" hydrophobic cavity can accommodate another lipophilic "curcumin" molecule. The hydrophilic shell is compatible with aqueous systems. Hydrophobic curcumin forms a hydrophilic shell, which can form a molecular emulsion that is more easily absorbed by the human body in water, thereby improving its bioavailability, and its bioavailability can be increased by about 40 times. UseΒCyclodextrins contain curcumin to form a molecular dispersion, so that more curcumin molecules are transported to the upper intestinal tract, where they are absorbed into the body.

According to research, it has been shown,ΒMechanism of lipid-lowering by cyclodextrin-curcumin inclusion complex may be enhanced by enhancing the bioavailability of peroxisome proliferator-activated receptors-γ(PPAR-γ) activity, thereby inhibiting the expression of LDL-C receptor genes, thereby reducing LDL-C levels. Due to its role in multiple molecular targets: ① PPAR-γ、PPAR-α, cholesteryl ester transfer protein (CETP) and lipoprotein lipase (LPL),β-cyclodextrin curcumin inclusion complex can reduce the level of TG; ② β-cyclodextrin curcumin inclusion complex affects the decomposition and synthesis of triglyceride lipoproteins. Therefore, β-cyclodextrin curcumin inclusion complex can reduce the expression of lipoprotein genes, thereby reducing serum TC and TG levels. Panahi et al. found that curcumin can affect all pathways of cholesterol metabolism related to statins, thereby reducing the use of statins and reducing the incidence of serious adverse drug reactions related to statins.

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