Sodium sulfobutylether-beta-cyclodextrin can better improve the dissolution rate of ketoprofen and enhance its bioavailability.

Ketoprofen is an arylalkanoic acid compound with analgesic, anti-inflammatory, and antipyretic effects. Its poor water solubility, however, impacts its clinical efficacy. Fukuda et al. compared the solubilizing effects of β-CD and SBECD on ketoprofen. In vitro dissolution tests showed that the SBECD-ketoprofen inclusion complex prepared by hot-melt extrusion achieved 91.6% drug dissolution in 0.1 mol·L⁻¹ hydrochloric acid solution at 30 min, while the β-CD-ketoprofen inclusion complex achieved only 55.4% under the same conditions. The results indicate that SBECD forms a more stable complex with ketoprofen than β-CD, significantly improving ketoprofen's dissolution rate and potentially its bioavailability.

Shandong Zhonghuan Zhongjie Biotechnology Co., Ltd. focuses on promoting the unlimited application of cyclodextrin derivatives. Collaborating with experts from Shandong University, Jiangnan University, Qilu University of Technology, and others in the cyclodextrin industry, we continuously optimize the production process of sulfobutylether-β-cyclodextrin sodium to provide stable, high-quality products and thoughtful, attentive service to meet the needs of customers across various industries and fields.