Carboxymethyl Beta Cyclodextrin

Carboxymethyl beta cyclodextrin is obtained by nucleophilic substitution of the hydroxyl group on beta-cyclodextrin by chloroacetic acid in an alkaline medium, and is a commonly used chiral additive in CE.

Name: Carboxymethyl beta cyclodextrin

Appearance: White powder

CAS No.: 218269-34-2

Molecular formula :C42H70-nO35· (CH2COONa)n

Molecular weight: 1135+80n

Solubility: Easily soluble in water

Package: 1g/bag , 100g/bag, 500g/bag, 1kg/bag or customized

Application

Carboxymethyl beta cyclodextrin is a compound formed by connecting the carboxymethyl group to the cyclodextrin cavity through an ether bond. It has the following characteristics: (1) The carboxymethyl group is linked to the edge of the cyclodextrin cavity through an ether bond, not only breaking the original hydrogen bond network of the cyclodextrin molecule was restored, and the oxygen atom in the carboxyl group could form a hydrogen bond with the hydrogen in the water molecule, which greatly improved the water solubility of the cyclodextrin; (2) The edge of the cyclodextrin cavity The carboxyl group is an anionic group, which can be dissociated into -COO- in a weakly acidic or alkaline environment, which can form a complex with metal ions and improve the electrostatic interaction with other compound molecules. According to the above characteristics, the Carboxymethyl beta cyclodextrin molecule with good water solubility can not only form inclusion complexes with other compounds, but also the carboxyl group contained in the molecule can enhance the hydrogen bond, static electricity, dipole and so on with other molecules. Therefore, it has a good application in medicine, separation analysis, biological science, environmental protection, sewage treatment and so on.