Hydroxypropyl gamma cyclodextrin
Subcategory:
Pharmaceutical Cyclodextrin
Hydroxypropyl-Gamma-Cyclodextrin;Hydroxypropyl-γ-Cyclodextrin;
Abbreviation: HP-γ-CD.
CAS NO. : 128446-34-4
Molecular formula: C48H80-nO40(C3H7O)n，n is the degree of substitution
Molecular weight :1297.2+58n，n is the degree of substitution
Testing Standards:
Hydroxypropyl-Gamma-Cyclodextrin | |
CAS No.：128446-34-4 | |
Test basis | Enterprise standard |
Test items | Index |
Appearance | This product is white or off-white amorphous or crystalline powder; odorless, slightly sweet taste; strong moisture attraction. Very soluble in water, soluble in ethanol, almost insoluble in acetone. |
pH | 5.0～8.5 |
Absorbance | Absorbance should not exceed 0.5 in the wavelength range of 220-350nm and 0.5 in the wavelength range of 350-750nm. |
Hydroxypropoxy content | 17.5%～29.1% |
Moisture content | ≤10.0％ |
Gamma cyclodextrin | ≤1.5% |
Scorch residue | ≤0.2％ |
Heavy metal | ≤10％ |
1,2-Propanediol | ≤0.5％ |
Active substance content | ≥95.0% |
Total aerobic bacteria | ≤1000cfu/g |
Total molds and yeasts | ≤100cfu/g |
Escherichia coli (E. coli) | Not detectable |
Product Features：
Hydroxypropyl Gamma Cyclodextrin solubilizes large molecules, such as cholesterol, for use in cell culture. Hydroxypropyl gamma cyclodextrin is similar to betacyclodextrin but solubilizes larger molecules.
Product Usage:
After hydroxypropylation of the product hydroxypropyl-γ-cyclodextrin, water solubility further increased to 80g/100ml (25 ℃), at the same time after hydroxypropylation of γ-cyclodextrin is no longer a single product, but a variety of substitutions coexist in the mixture, in the molecular inclusion with the guest is not easy to generate the inclusion of crystalline precipitation, in general, the hydroxypropyl-γ-cyclodextrin has a higher solubility in water, a stronger resistance to crystallization precipitation ability. Overall, hydroxypropyl-γ-cyclodextrin has higher solubility in water and stronger resistance to crystallization. γ-cyclodextrin solubility in water is 23.2g/100ml (25℃), but the solubility still limits its application in some cases.
It is recommended to be used in higher value-added products, such as pharmaceuticals, health care products, cosmetics and other specialty materials or hydroxypropyl-β-cyclodextrin incapable of encapsulation of larger molecules to deal with.
Packaging storage
Packing: in accordance with the pharmaceutical packaging
Packing specification: 1kg/bag; 2kg/bag; 10kg/drum; 20kg/drum
Storage: Sealed and kept in dry place
keyword:
Hydroxypropyl-Gamma-Cyclodextrin