Injection grade hydroxypropyl betacyclodextrin

The introduction of hydroxypropyl (2-hydroxypropyl) destroys the hydrogen bonds within the ring of β-cyclodextrin, which not only retains the cyclodextrin cavity, but also overcomes the main shortcoming of poor water solubility of β-cyclodextrin.

Basic information

Name:Hydroxypropyl betacyclodextrin

CAS No.:128446-35-5

DMF No.:030168

CEP No.:CEP 2022-219 - Rev 00

Qaulity : Injection grade/Oral grade/Technical grade

Package: 500g/bag , 1kg/bag,  10kg/drum , 20kg/drum or customized

Product features

1. Solubilize and help dissolve poorly soluble drugs, improve the solubility of active ingredients in oily drugs, target drug delivery and protect the effectiveness of drug ingredients.

2. Improve drug bioavailability, increase the efficacy of the drug or reduce the dosage.

3. Adjust or control the release rate of drugs to reduce drug side effects.

4. Cover up bad smells.

Scope of application

Hydroxypropyl betacyclodextrin can be used in oral preparations, injection preparations, mucosal drug delivery systems (including nasal mucosa, rectum, cornea, etc.), transdermal absorption drug delivery systems, carriers for lipophilic targeted drugs, and can also be used as protein protectants and stabilizers.

Injection grade hydroxypropyl betacyclodextrin is a high-purity, pharmaceutical excipient widely used in the formulation of injectable drugs. As a chemically modified derivative of beta-cyclodextrin, it possesses improved water solubility, enhanced safety, and superior inclusion capacity, making it highly suitable for parenteral drug delivery systems. This material is produced under strict GMP conditions to ensure compliance with pharmacopeial standards, including low endotoxin content, high purity, and excellent biocompatibility, which are critical for injection-grade applications.

One of the most significant features of injection grade hydroxypropyl betacyclodextrin is its ability to form stable inclusion complexes with poorly soluble or unstable drug molecules. By encapsulating the drug in its hydrophobic cavity while maintaining a hydrophilic exterior, it can improve solubility, enhance stability, and control drug release. This property is particularly valuable for developing injectable formulations of drugs that otherwise have limited water solubility, thereby improving bioavailability and therapeutic efficacy.

The use of injection grade hydroxypropyl betacyclodextrin extends to various therapeutic areas, including oncology, cardiovascular medicine, antifungal therapy, and hormone delivery. For example, it can be used to stabilize lipophilic anticancer agents, reduce irritation of certain intravenous drugs, and enable the safe injection of compounds that would otherwise precipitate in aqueous solution. Its versatility in drug compatibility allows pharmaceutical developers to expand formulation possibilities for both small molecules and biologics.