Piroxicam-beta -cyclodextrin Complex
Subcategory:
Other Cyclodextrins
Product Name : Piroxicam-beta-cyclodextrin complex
CAS No.: 96684-39-8
Molecular formula: C42H70O35. xC15H13N3O4S
Package: 500g/bag , 1kg/bag , 2kg/bag, 10kg/drum or customized
Features and applications:
It also known as inflammatory pain piroxicam beta-cyclodextrin is a process unique, according to a certain proportion of the pharmaceutical grade of piroxicam with pharmaceutical grade B-cyclodextrin inclusion is refined, the inclusion complexes with piroxicam monomer phase comparison, has less odor, more stable, more stable medicine releasing speed, mainly used in anti-inflammatory analgesic drugs.
| Test Standard | Enterprise Standard |
| ITEMS | CRITERIA |
| Appearance | This product should be light yellow powder, odorless, tasteless. |
| Identification | The retention time of the major peak of sample solution corresponds to the standard solution. |
| Water solution pH | pH5.0~8.0 |
| Color of Solution | 0.50g/100ml water solution is light yellow. |
| Ammonium Ion | ≤0.5% |
| Free Piroxicam | ≤0.5% |
| Loss on Drying | ≤6.0% |
| Content of Piroxicam | 9.5%~11.5% |
| Packaging and storage | Preserve in well-closed containers. |
Piroxicam - β - cyclodextrin complex represents a significant advancement in the field of pharmaceuticals. This complex combines the well - known anti - inflammatory drug piroxicam with β - cyclodextrin, resulting in a product with enhanced properties and improved therapeutic potential.
Piroxicam is a non - steroidal anti - inflammatory drug (NSAID) that has been used for decades to relieve pain, reduce inflammation, and lower fever. It works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins. Prostaglandins are substances that play a key role in the inflammatory process, pain perception, and fever. However, piroxicam has some limitations in terms of its solubility and bioavailability.
β - cyclodextrin is a cyclic oligosaccharide composed of seven glucose units. It has a unique structure with a hydrophobic cavity and a hydrophilic outer surface. This structure allows it to form inclusion complexes with various hydrophobic molecules. In the case of the piroxicam - β - cyclodextrin complex, β - cyclodextrin acts as a carrier molecule for piroxicam.
When piroxicam and β - cyclodextrin are combined, piroxicam molecules are entrapped within the hydrophobic cavity of β - cyclodextrin through non - covalent interactions such as van der Waals forces and hydrophobic interactions. This complex formation has several advantages.
keyword:
Piroxicam-beta -cyclodextrin Complex