Oral grade hydroxypropyl betacyclodextrin manufacturers

The introduction of hydroxypropyl (2-hydroxypropyl) destroys the hydrogen bonds within the ring of β-cyclodextrin, which not only retains the cyclodextrin cavity, but also overcomes the main shortcoming of poor water solubility of β-cyclodextrin.

Basic information

Name:Hydroxypropyl betacyclodextrin

CAS No.:128446-35-5

DMF No.:030168

CEP No.:CEP 2022-219 - Rev 00

Qaulity : Injection grade/Oral grade/Technical grade

Package: 500g/bag , 1kg/bag,  10kg/drum , 20kg/drum or customized

Product features

1. Solubilize and help dissolve poorly soluble drugs, improve the solubility of active ingredients in oily drugs, target drug delivery and protect the effectiveness of drug ingredients.

2. Improve drug bioavailability, increase the efficacy of the drug or reduce the dosage.

3. Adjust or control the release rate of drugs to reduce drug side effects.

4. Cover up bad smells.

Scope of application

Hydroxypropyl betacyclodextrin can be used in oral preparations, injection preparations, mucosal drug delivery systems (including nasal mucosa, rectum, cornea, etc.), transdermal absorption drug delivery systems, carriers for lipophilic targeted drugs, and can also be used as protein protectants and stabilizers.

Oral Grade Hydroxypropyl Betacyclodextrin: Advantages and Applications

In the pharmaceutical and nutraceutical industries, the quest for ingredients that enhance solubility, stability, and bioavailability is never-ending. Oral grade hydroxypropyl betacyclodextrin (HPBCD) has emerged as a versatile and highly effective excipient that addresses these challenges. This modified cyclodextrin, derived from natural sources and rigorously purified for oral use, offers a unique molecular structure capable of forming inclusion complexes with poorly soluble compounds. The advantages of using oral grade hydroxypropyl betacyclodextrin extend across improved drug delivery, enhanced product stability, and broad applicability in formulations, making it an invaluable tool for developers and manufacturers.

The applications of oral grade hydroxypropyl betacyclodextrin are diverse. It is used in oral solid dosages like tablets and capsules, liquid suspensions, and even orally disintegrating films. In nutraceuticals, it improves the delivery of compounds like curcumin, coenzyme Q10, and omega-3 fatty acids. In pharmaceuticals, it is employed for drugs ranging from antifungals to anti-inflammatories. Its versatility also extends to functional foods and beverages, where it enhances the stability and bioavailability of bioactive ingredients.

In summary, oral grade hydroxypropyl betacyclodextrin is a multifunctional excipient that offers solubility enhancement, stability improvement, and excellent safety profiles. Its role in advancing oral formulation science cannot be overstated, providing solutions that benefit both manufacturers and end-users. For industries focused on innovation and quality, oral grade hydroxypropyl betacyclodextrin is an enabling technology that continues to expand the possibilities of what oral products can achieve.