Oral grade hydroxypropyl betacyclodextrin

The introduction of hydroxypropyl (2-hydroxypropyl) destroys the hydrogen bonds within the ring of β-cyclodextrin, which not only retains the cyclodextrin cavity, but also overcomes the main shortcoming of poor water solubility of β-cyclodextrin.

Basic information

Name:Hydroxypropyl betacyclodextrin

CAS No.:128446-35-5

DMF No.:030168

CEP No.:CEP 2022-219 - Rev 00

Qaulity : Injection grade/Oral grade/Technical grade

Package: 500g/bag , 1kg/bag,  10kg/drum , 20kg/drum or customized

Product features

1. Solubilize and help dissolve poorly soluble drugs, improve the solubility of active ingredients in oily drugs, target drug delivery and protect the effectiveness of drug ingredients.

2. Improve drug bioavailability, increase the efficacy of the drug or reduce the dosage.

3. Adjust or control the release rate of drugs to reduce drug side effects.

4. Cover up bad smells.

Scope of application

Hydroxypropyl betacyclodextrin can be used in oral preparations, injection preparations, mucosal drug delivery systems (including nasal mucosa, rectum, cornea, etc.), transdermal absorption drug delivery systems, carriers for lipophilic targeted drugs, and can also be used as protein protectants and stabilizers.

One of the primary benefits of oral grade hydroxypropyl betacyclodextrin is its ability to significantly enhance the solubility and bioavailability of hydrophobic active ingredients. Many pharmaceuticals and nutraceuticals suffer from poor water solubility, which limits their absorption in the gastrointestinal tract. By encapsulating these molecules within its hydrophobic cavity, HPBCD increases their dissolution rate and facilitates better uptake. This is particularly critical for drugs with low oral bioavailability, enabling more effective dosing and therapeutic outcomes. The use of oral grade hydroxypropyl betacyclodextrin can transform challenging compounds into viable products.

Moreover, oral grade hydroxypropyl betacyclodextrin improves the stability of sensitive ingredients. It protects molecules from oxidation, hydrolysis, and light-induced degradation by shielding them within its cyclic structure. This stabilizing effect extends the shelf life of products and ensures consistency in potency and efficacy. For example, it is widely used to stabilize vitamins, hormones, and antioxidants in dietary supplements and pharmaceuticals. The reliability offered by oral grade hydroxypropyl betacyclodextrin is essential for maintaining product quality from manufacturing to end-use.

Another advantage is its safety and biocompatibility. As an oral grade material, it meets stringent purity standards and is non-toxic, non-irritating, and well-tolerated in humans. Regulatory agencies worldwide have approved its use in oral formulations, making it a trusted choice for both prescription and over-the-counter products. Its ability to mask unpleasant tastes and odors further enhances patient compliance, especially in pediatric and geriatric formulations.