2,6-Di-O-methyl-Beta-cyclodextrin

2.6-Di-O-methyl-Beta-cyclodextrin CAS 51166-71-3

Product Introduction

2.6-di-O-methyl-beta-CyclodextrinWith strong water and oil-solubility, as the stromal molecule to include the complexes and to be used in including of drugs spices etc.It can change the original natures of materials ,in medical field ,it can promote the dissolusion efficiency of the drugs, enhancing bioavailability and solubility of drugs, so that to reduce the dose but increase the efficacy. it can adjust and controls the releasing of drugs, to enhance the stability. It can changes mmucosa sbsorption in drugs, specially for the oil soluble molecules it can be more effective to increase the water solubility.

Basic information

Product Name : 2.6-di-O-methyl-beta-Cyclodextrin

CAS NO. : 51166-71-3

Synonyms : 2.6-di-O-methyl-β-Cyclodextrin

Abbreviation ：DMBCD

Molecular Formula : C56H98O35

Molecular Weight : 1331.36

Standard : enterprise standard

Usage of 2.6-di-o-methyl-beta-cyclodextrin

Can increase the solubility of the medicine and biological availability.

Can add up the good effect and decrease the dose.

Can control or adjust the reactive speed, lower the drug toxicity and enhance the stability of drugs.

Especially 2.6-dimethyl-beta-cyclodextrin is more effective for the oil-soluble molecules of water-soluble.

Characteristics of Methyl Beta Cyclodextrin and Its Application in Coating Thickener

Methyl beta cyclodextrin (M-β-CD) is the most effective cosolvent for insoluble substances and the best stabilizer for many chemicals. Because M-β-CD has excellent solubilization and inclusion, and because it is soluble in water and organic solvents, it is widely used in medicine, food, pesticide, cosmetics, daily chemicals, chemical industry, textile dyeing and finishing, chromatographic analysis and functional materials.

2,6-Di-O-methyl-β-cyclodextrin (2,6-DM-β-CD) is a chemically modified derivative of β-cyclodextrin that has gained significant attention in pharmaceutical, chemical, and biochemical research due to its enhanced solubility and selective molecular encapsulation properties. Cyclodextrins are cyclic oligosaccharides composed of glucose units linked by α-1,4-glycosidic bonds, forming a hydrophobic cavity capable of forming inclusion complexes with various guest molecules. The methylation of the 2 and 6 hydroxyl positions on the glucose units of β-cyclodextrin alters its physicochemical characteristics, making 2,6-DM-β-CD particularly useful in drug formulation, biotechnology, and industrial applications.  

One of the most notable advantages of 2,6-DM-β-CD is its improved water solubility compared to native β-cyclodextrin. Unmodified β-cyclodextrin has limited solubility in water, which restricts its practical applications. However, the introduction of methyl groups at the 2 and 6 positions reduces intermolecular hydrogen bonding, thereby increasing solubility. This property is especially valuable in pharmaceutical formulations, where higher solubility can enhance drug bioavailability. Many poorly water-soluble drugs, such as antifungal agents, anti-inflammatory compounds, and anticancer drugs, have been successfully complexed with 2,6-DM-β-CD to improve their dissolution rates and stability.  

In addition to solubility enhancement, 2,6-DM-β-CD exhibits selective molecular recognition capabilities. The methylation pattern influences the size and polarity of the cyclodextrin cavity, allowing it to preferentially bind certain guest molecules based on size, shape, and hydrophobicity. This selectivity is exploited in separation sciences, where 2,6-DM-β-CD is used as a chiral selector in capillary electrophoresis and high-performance liquid chromatography (HPLC) to separate enantiomers. The ability to distinguish between stereoisomers is crucial in drug development, as different enantiomers of a pharmaceutical compound may have varying biological activities or toxicities.